报告人简介：
Arjun G. Yodh教授是宾夕法尼亚大学James M Skinner 科学教授和宾大物质结构研究实验室及其国家科学基金会材料科学研究及工程中心（NSF-MRSEC）的主任。他所在的院系是物理学与天文学系，同时也在医学院的放射肿瘤学系兼职。Yodh在康奈尔大学获得学士学位，在哈佛大学获得博士学位。他在AT&T贝尔实验室做了两年博士后之后，于1988年获得宾夕法尼亚大学教职。他目前的研究兴趣包括软物质物理、生物医学光学、和光学的基础和应用问题。他在这些领域发表了超过250篇文章。在生物医学光学方向，他的实验室开展了一系列临床前和临床研究，从光传输，图像重建等基础问题，到鉴别相关临床问题，以及光学方法在这些临床问题中的应用等。目前的临床应用包括大脑和乳腺的功能成像和监测，监测癌症治疗中的肿瘤血液动力学，研究病人四肢、脊柱及其他组织的缺血等。

Biography:
Arjun G. Yodh is the James M. Skinner Professor of Science at the University of Pennsylvania, and the Director of Penn’s The Laboratory for Research on the Structure of Matter and its NSF-Materials Science Research & Engineering Center (NSF-MRSEC). His home department is Physics & Astronomy, and he holds a secondary appointment in the Department of Radiation Oncology in the Medical School. Yodh received his B.Sc. from Cornell University and his Ph.D. from Harvard University. He joined the University of Pennsylvania faculty in 1988, following a two-year postdoctoral fellowship at AT&T Bell Laboratories. His current interests span fundamental and applied questions in soft matter physics, biomedical optics, and the optical sciences. He has published more than 250 papers in these fields. Per Biomedical Optics, his laboratory carries out pre-clinical and clinical research that explores issues ranging from fundamental questions about light transport, image reconstruction and optical technology development, to identification of relevant clinical problems and application of optical methodologies to those clinical problems. Current clinical applications include functional imaging/monitoring in brain and breast, monitoring tumor hemodynamics during cancer therapy, and investigation of patients with ischemia in limbs, spine and other tissues.

报告摘要：
在乳腺癌成像、大脑的功能激活及临床研究、癌症治疗监测和肌肉疾病的研究等各种医疗解决方案中，功能性扩散光学成像和组织的光谱学技术逐渐成为一种重要的诊断方法。在简要介绍扩散光学的概念后，我将回顾我的实验室多项近期的临床研究，特别是那些针对乳腺癌和脑功能的研究。乳腺癌研究的核心在于试点性的临床试验，目前已经进展到了对扩散光的定量评估，以用于肿瘤的检测和表征，也有助于癌症治疗检测等衍生问题的解决。扩散光学方法的第二个重要应用是在脑功能和生理学研究领域，这个领域中，组织氧消耗、维管联结和调节效应之间的相互作用甚少为人所知。这一方法在脑研究中的应用将会以多个示例介绍，包括临床上对急性缺血性脑卒中病人的看护等。

Abstract:
Functional diffuse optical imaging and spectroscopy of tissue is gaining momentum as a diagnostic in a variety of medical scenarios including breast cancer imaging, functional activation and clinical studies of brain, cancer therapy monitoring and the investigation of muscle disease. After a short introduction to diffuse optics, I will review several recent clinical studies from my lab, particularly those oriented towards breast cancer and brain function. Central to the breast cancer effort is a pilot clinical trial which has taken important steps towards quantitative assessment of diffuse optics for detection and characterization of tumors, and helps to spin-off problems such as cancer therapy monitoring. A second important application of diffuse optical methods is in the area of brain function and physiology wherein the interplay between tissue oxygen consumption, vascular supply, and regulatory effects remains poorly understood. The utility of this approach in brain will be demonstrated in several contexts, including the care of acute ischemic stroke (AIS) patients in the clinic.