报告题目：DNA保护银纳米团簇的合成和应用
The Synthesis and Applications of DNA Protected Silver Nanoclusters

时 间：2015年5月11日 10:50-12:00
地 点：武汉光电国家实验室A101
报 告 人：汪尔康 院 士，中国科学院长春应用化学研究所
邀 请 人：申 燕 教 授

报告人简介：
汪尔康院士，曾任中科院长春应化所所长。1952年上海沪江大学毕业。1959年在捷克获博士学位（导师诺贝尔奖获得者J. 海洛夫斯基院士），1991年当选中科院院士。1993年当选第三世界科学院院士。2006年当选日本分析化学学会荣誉会员。发表论文900多篇，SCI收录800多篇，总引25000次。H指数77。国际大会报告和专题报告100多次，在26个国家和地区作学术报告200多次。获国家（自然科学奖）3项和省部级奖10项及吉林省首届科技进步特殊贡献奖，国际奖2项，发明专利40项。涉及分析化学，电化学与电分析化学，环境与生命科学分析。主编《21世纪的分析化学》（1999）和《生命分析化学》（2006）。在美、法、日和香港的5所大学聘为客座教授。为九种国际化学杂志编委，国际顾问委员会委员；任《分析化学》主编。汪尔康培养博士和硕士研究生100多名，博士后13名。他本人多次获优秀导师称号。获选全球高引用研究者（2002-2012）。

Biography:
Erkang Wang graduated in chemistry at the University of Shanghai (1952). Ph.D. degree received in Prague from the Czechoslovak Academy of Sciences in 1959 under Professor J. Heyrovsky, Nobel Prize laureate. He is a member of CAS (1991) and of the Academy of Sciences for the Developing World (TWAS)(1993), Honorary Member of the Japanese Analytical Chemistry Society (2006). He is editor-in-chief of Analytical Chemistry (Chinese). He was previously deputy director and director of CIAC, CAS. His awards include: National Science Congress Award; 5 CAS Awards; 5 Awards and 1 Special Outstanding Award in Jilin Province; 3 National Natural Science Awards; first winner of the 10th Kharazmi International Festival, Tehran, Iran; and the World Intellectual Property Organization, Geneva, 1997, and 40 invention patents. He gave over 100 plenary, key and invited lectures in international symposia, and over 200 seminars and reports in 26 countries and regions. He has being directed 13 postdocs and over 100 graduates, and among them 3 received national hundred excellent doctorate thesis awards, 2 received special President awards and 4 received excellent doctorate thesis awards of CAS. He has been awarded as an excellent graduate supervisor many times in CAS. He is known for his advancements in bioelectrochemistry, sensors and biosensors, hyphenated interface with separation technics, microfluidics and electroanalytical chemistry. He published about 800 papers in intenational SCI journals cited over 25,000 times with H index of 77. He is selected in the global "Highly Cited Researcher 2014" by ISI Web of Science (SCI) in the past 11 years (2002-2012).

报告摘要：
因为其独特的与尺寸相关的光、电、磁和催化性能，银纳米团簇吸引了大量的研究兴趣，我们团队一直专注于研究用基于DNA保护的银纳米团簇监测DNA、 Hg2+和巯基化合物。我们发现发生在DNA/银纳米复合物与G-四链体/血红素之间光诱导电子转移（PET），伴随着DNA/银纳米荧光减弱。这一新的PET系统使目标生物分子如DNA和敏感性高的ATP获得特异性和多样性的检测。我们首次开发出一种以DNA单体作为支架的高收率银纳米簇的合成方法。在这项研究中，我们采用密度泛函计算理论解释了DNA保护的银纳米团簇的形成机理以及为什么富胞嘧啶DNA是荧光银纳米簇的良好支架。我们的结果对DNA保护荧光银纳米簇进一步实验和理论研究提供了基本指导思想，最终可能有助于程序化合成具有光致发光性能的DNA稳定银纳米团簇。

Abstract:
Silver nanoclusters have attracted much research interest because of their unique size-dependent optical, electronic, magnetic, and catalytic properties. Our group has focused on the detection of DNA, Hg2+ and biothiols based on DNA protected silver nanoclusters. We have reported photoinduced electron transfer (PET) between DNA/Ag NCs and G-quadruplex/hemin complexes, accompanied by a decrease in the fluorescence of DNA/Ag NCs. The novel PET system enabled the specific and versatile detection of target biomolecules such as DNA and ATP with high sensitivity. Recently, we have developed a high-yield synthesis of silver nanoclusters using DNA monomers as the scaffolds for the first time. In the study, we have explained the mechanism of the formation of DNA-protected silver nanoclusters and the reason why cytosine-rich DNA strands are good scaffolds for fluorescent silver nanoclusters by using density-functional computations. Our results provide basic guidelines for further experimental and theoretical studies on DNA-protected fluorescent silver nanoclusters and may ultimately contribute to the programmed synthesis of DNA-stabilized silver nanoclusters with photoluminescence properties.

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