时 间：2019年1月3日15:00-16:30

地 点：武汉光电国家研究中心A101

报 告人：徐臣杰博士，助理教授，新加坡南洋理工大学化学和生物工程系

邀 请人：王平 教授

报告题目（Title）：

基于微纳米技术的经皮给药和无创伤检测

Transdermal drug delivery and noninvasive detection based on micro-nano technology

报告摘要 (Abstract)：

经皮给药是指药物涂布或敷贴于皮肤表面的一种给药方法。为使更多药物能透皮，一些药剂学、化学及物理手段被用于促进药物的透皮吸收。最常用的方法是使用各种类型透皮吸收促进剂或者使用具有良好透皮能力的物质作为药物载体。徐博士致力于基于微针和纳米颗粒的经皮给药技术。通过新材料的研发，他的团队设计了具有独特功能的微针皮肤贴，从而帮助治疗和检测在皮肤、癌症、眼科和牙科等等方面的医学难题。其中最具有代表性的工作是对非正常疤痕的治疗和检测。例外，徐博士团队也基于最新核酸纳米技术，开发了能经皮的抗癌载药体系。

Percutaneous drug delivery refers to the drug coating or application on the skin surface of a drug delivery method. In order to make more drugs transdermal, some pharmaceutical, chemical and physical means are used to promote drug transdermal absorption. The most common method is to use various types of transdermal absorption promoters or substances with good transdermal ability as drug carriers. Dr. Xu is working on transdermal drug delivery techniques based on microneedles and nanoparticles. Through the development of new materials, his team designed microacupuncture skin patches with unique functions to help treat and detect medical problems in skin, cancer, ophthalmology and dentistry. One of the most representative work is the treatment and detection of abnormal scars. In addition, based on the latest nucleic acid nanotechnology, Dr. Xu's team has developed a drug delivery system capable of transdermal anticancer.

报告人简介 (Biography)：

徐臣杰博士于2002本科毕业于南京大学强化班化学专业，2004自香港科技大学获得理学硕士学位，2009年于美国布朗大学取得博士学位。在哈佛大学医学院进行博士后研究后，他于2012年加入新加坡南洋理工大学化学和生物工程系。到目前为止，他共发表了100余篇研究论文，已申请了9个国际专利，出版了2本书籍。其论文发表的杂志包括Nature Biotechnology, Nature Biomedical Engineering, Nature Communication, Nature Protocol 等. 被引用8000次以上。

Dr. Xu obtained his B.Sc. degree in Department of Intensive Instruction of Nanjing University (2002). From 2002 to 2004, he studied at HKUST under the direction of Prof. Bing Xu (Brandeis University) about the synthesis and functionalization of magnetic nanoparticles for protein separation. From 2004 to 2005, he was a visiting scholar in the molecular imaging program at Stanford with Prof. Jianghong Rao, designing self-illuminating quantum dots for cancer imaging. From 2005 to 2009, he did his PhD at Prof. Shouheng Sun’s group of Brown University, focusing on the synthesis of novel platforms of magnetic nanoparticles for biomedical applications including drug delivery and molecular imaging. From 2009-2012, he did his postdoc with Prof. Jeffrey M. Karp at HST in the field of stem cell engineering and drug delivery. He is currently an assistant professor at School of Chemical and Biomedical Engineering, Nanyang Technology University, Singapore. His research interest is the transdermal applications of micro/nano-technologies such as microneedles and nanoparticles.