Photodynamic therapy of cancer — Challenges of multidrug resistance
Zheng Huang, Yih-Chih Hsu, Li-Bo Li, Luo-Wei Wang, Xiao-Dong Song, Christine M. N. Yow, Xia Lei, Ali I. Musani, Rong-Cheng Luo, Brian J. Day
J. Innov. Opt. Health Sci. 08, 1530002 (2015)

Photodynamic therapy (PDT) of cancer is a two-step drug-device combination modality, which involves the topical or systemic administration of a photosensitizer followed by light illumination of cancer site. In the presence of oxygen molecules, the light illumination of photosensitizer (PS) can lead to the generation of cytotoxic reactive oxygen species (ROS) and consequently destroy cancer. Similar to many other anticancer therapies, PDT is also subject to intrinsic cancer resistance mediated by multidrug resistance (MDR) mechanisms. This paper will review the recent progress in understanding the interaction between MDR transporters and PS uptake. The strategies that can be used in a clinical setting to overcome or bypass MDR will also be discussed.

Keywords: Photodynamic therapy; photosensitizer; multidrug resistance; cancer

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A.C. Tedesco, F.L. Primo, M. Beltrame. 2016. Phthalocyanines: Synthesis, Characterization and Biological Applications of Photodynamic Therapy (PDT), Nanobiotechnology, Magnetohyperthermia and Photodiagnosis (Theranostics). Reference Module in Materials Science and Materials Engineering. [CrossRef]

Cristiano Ceron Jayme, Italo Rodrigo Calori, Antonio Claudio Tedesco. (2016) Spectroscopic analysis of aluminum chloride phthalocyanine in binary water/ethanol systems for the design of a new drug delivery system for photodynamic therapy cancer treatment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 153, 178-183. Online publication date: 1-Jan-2016. [CrossRef]

Buhong Li, Brian C. Wilson. (2015) Editorial. Journal of Innovative Optical Health Sciences 08:01. Online publication date: 1-Jan-2015. [Abstract | PDF (59 KB) | PDF Plus (69 KB)]

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