武汉光电论坛第103期

报告题目：临床生物光子学
Clinical Biophotonics

时 间：2015年10月13日16:00-18:00
地 点：武汉光电国家实验室A101
报 告 人：Prof. Jürgen Popp, Friedrich-Schiller University Jena 德国耶拿大学
邀 请 人：骆清铭 教授

报告人简介：
Jürgen Popp在德国的埃朗根维尔茨堡大学化学专业学习。在拿到物理化学专业的博士学位之后，他开始了耶鲁大学的博士后工作。随后在2002年，他回到了维尔茨堡大学并获得教授资格。从2002年起，他在席勒耶拿大学担任物理化学研究所首席教授。此外，从2006年起他成为莱布尼兹光子技术研究所的主任。他的主要研究方向是生物光子学，应用和发展频率、时间、空间分辨的激光技术，用于生物医学诊断、治疗以及环境食物的分析。尤其在临床医学里，应用和发展线性和非线性拉曼技术方面取得了突破性进展。在这些研究中，拉曼技术解决了病理学、肿瘤学和败血症的感染等领域的各种临床需求。他已经发表了550多篇论文，是光谱仪器领域12项专利的发明者。他还是《生物光子学》期刊的主编和创始编辑。2012年，他获得了罗马尼亚克鲁日“ 巴比什-博雅伊”大学的名誉博士学位。Jürgen Popp教授是2013年Robert Kellner Lecture Award的得主，并且在2016年他将得到久负盛名的匹兹堡光谱学奖。

Biography:
Jürgen Popp studied chemistry at the universities of Erlangen and Wuerzburg, Germany. After his PhD in Physical Chemistry, he joined Yale University for postdoctoral work. He subsequently returned to Wuerzburg University where he finished his habilitation in 2002. Since 2002, he holds a chair for Physical Chemistry at the Friedrich-Schiller University Jena. Furthermore, he is the Scientific Director of the Leibniz Institute of Photonic Technology, Jena, since 2006. His core research focus is biophotonics, i.e. the development and application of frequency-, time- and spatially resolved innovative laser microspectroscopical methods and techniques for biomedical diagnostics as well as environmental and food analysis. Corner stones are the development and application of linear and non-linear Raman-technologies with particular focus on clinical diagnosis. In this context,Raman methods are utilized and developed according to the needs of pathology, oncology, and infection/ sepsis. He has published more than 550 journal papers and has been named as an inventor on 12 patents in the field of spectroscopic instrumentation. He is founding editor and Editor-in-Chief of the Journal of Biophotonics. In 2012, he received an honorary doctoral degree from Babeş-Bolyai University in Cluj-Napoca, Romania. Professor Jürgen Popp is the recipient of the 2013 Robert Kellner Lecture Award and in 2016 he will receive the prestigious Pittsburgh Spectroscopy Award.

报告摘要：
理解疾病的原因、疾病的早期识别、靶向疾病治疗、治疗反应的预测、以及监测治疗的成功是现代生物医学的几项基本愿景。在过去的几年中，生物光子学见证了光学和光子学手段的发展具备迎接这些挑战的潜力。在这种情况下，如拉曼光谱等光谱方法尤其值得关注。这里，我们将介绍无损线性和非线性拉曼光谱方法在临床诊断中的应用。我们将展现一种基于芯片的细菌分离技术，用于快速识别病原并探测其对抗生素的抵抗力，这对病人的生存至关重要。我们还将报告这一技术如何应用于识别血液循环中的肿瘤细胞并同时监测其治疗药物。此外，我们将介绍光谱方法在体外和体内的组织病理学中的应用，以对癌症进行早期诊断。

Abstract:
Understanding the cause of diseases, early disease recognition, targeted disease treatment, predication of therapeutic response and monitoring treatment success; are the underlying principles of the vision associated with modern biomedicine. In the past years Biophotonics has witnessed the development of optical / photonic approaches that are potentially in a position to meet these aforementioned challenges. In this context, spectroscopic approaches like e.g. Raman spectroscopy are especially noteworthy. Here, we introduce into the application of non-invasive spectroscopic approaches with special emphasis on linear and non-linear Raman approaches for clinical diagnosis. We will present chip-based bacterial isolation strategies for a fast pathogen identification and the determination of their antibiotic resistances, which is crucial for patient’s survival. Moreover, we report about Raman on-chip approaches for the identification of circulating tumor cells and therapeutic drug monitoring. Furthermore, we introduce spectroscopic approaches for ex-vivo and in-vivo spectral histopathology for an early diagnosis of cancer.

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