Multi-layered tissue head phantoms for noninvasive optical diagnostics

M. S. Wróbel

Department of Metrology and Optoelectronics, Gdańsk University of Technology, Gabriela Narutowicza Street 11/12, 80-233 Gdańsk, Poland

A. P. Popov

Optoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, Finland

A. V. Bykov

Optoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, Finland

M. Kinnunen

Optoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, Finland

M. Jędrzejewska-Szczerska

Department of Metrology and Optoelectronics, Gdańsk University of Technology, Gabriela Narutowicza Street 11/12, 80-233 Gdańsk, Poland

V. V. Tuchin

Optoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, Finland

Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov 410012, Russia

Institute of Precise Mechanics and Control, Russian Academy of Sciences, Saratov 410028, Russia

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient and absorption coefficient μ_a) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide (ZnO) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

Keywords: Tissue-mimicking phantoms; optical properties; near-infrared spectroscopy; head model

Cited by (7):

Alexey N Bashkatov, Elina A Genina, Vyacheslav I Kochubey, Valery V Tuchin. (2016) Quantification of tissue optical properties: perspectives for precise optical diagnostics, phototherapy and laser surgery. Journal of Physics D: Applied Physics 49:50, 501001. Online publication date: 21-Dec-2016. [CrossRef]

Idit Feder, Maciej Wróbel, Hamootal Duadi, Małgorzata Jędrzejewska-Szczerska, Dror Fixler. (2016) Experimental results of full scattering profile from finger tissue-like phantom. Biomedical Optics Express 7:11, 4695. Online publication date: 1-Nov-2016. [CrossRef]

E Liakhov, O Smolyanskaya, A Popov, E Odlyanitskiy, N Balbekin, M Khodzitsky. (2016) Fabrication and characterization of biotissue-mimicking phantoms in the THz frequency range. Journal of Physics: Conference Series 735, 012080. Online publication date: 1-Aug-2016. [CrossRef]

Maciej S. Wróbel, Alexey P. Popov, Alexander V. Bykov, Valery V. Tuchin, Małgorzata Jędrzejewska-Szczerska. (2016) Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering. Biomedical Optics Express 7:6, 2088. Online publication date: 1-Jun-2016. [CrossRef]

K. Karpienko, M. Gnyba, D. Milewska, M. S. Wróbel, M. Jędrzejewska-Szczerska. (2016) Blood equivalent phantom vs whole human blood, a comparative study. Journal of Innovative Optical Health Sciences 09:02. Online publication date: 1-Mar-2016. [Abstract | PDF (295 KB) | PDF Plus (322 KB)]

M.S. Wróbel. (2016) Non-invasive blood glucose monitoring with Raman spectroscopy: prospects for device miniaturization. IOP Conference Series: Materials Science and Engineering 104, 012036. Online publication date: 21-Jan-2016. [CrossRef]

Naman Agarwal, Jiho Yoon, Enric Garcia-Caurel, Tatiana Novikova, Jean-Charles Vanel, Angelo Pierangelo, Alexander Bykov, Alexey Popov, Igor Meglinski, Razvigor Ossikovski. (2015) Spatial evolution of depolarization in homogeneous turbid media within the differential Mueller matrix formalism. Optics Letters 40:23, 5634. Online publication date: 1-Dec-2015. [CrossRef]

Read More: http://www.worldscientific.com/doi/abs/10.1142/S1793545815410059