J. Lademann
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
F. Knorr
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
H. Richter
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
S. Jung
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
M. C. Meinke
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
E. Rühl
Physical Chemistry, Institute of Chemistry, and Biochemistry, Freie Universität Berlin Takustr. 3, Berlin 14195, Germany
U. Alexiev
Department of Physics, Freie Universität Berlin, Arnimallee 14, Berlin 14195, Germany
M. Calderon
Physical Chemistry, Institute of Chemistry, and Biochemistry, Freie Universität Berlin Takustr. 3, Berlin 14195, Germany
A. Patzelt
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany
For at least two decades, nanoparticles have been investigated for their capability to deliver topically applied substances through the skin barrier. Based on findings that nanoparticles are highly suitable for penetrating the blood–brain barrier, their use for drug delivery through the skin has become a topic of intense research. In spite of the research efforts by academia and industry, a commercial product permitting the nanoparticle-assisted delivery of topically applied drugs has not yet been developed. However, nanoparticles of approximately 600 nm in diameter have been shown to penetrate efficiently into the hair follicles, where they can be stored for several days. The successful loading of nanoparticles with drugs and their triggered release inside the hair follicle may present an ideal method for localized drug delivery. Depending on the particle size, such a method would permit targeting specific structures in the hair follicles such as stem cells or immune cells or blood vessels found in the vicinity of the hair follicles.
Keywords: Skin barrier; penetration; stratum corneum ; hair follicles; triggered release
Cited by (12):
Fitsum Feleke Sahle, Christian Gerecke, Burkhard Kleuser, Roland Bodmeier. (2017) Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications. International Journal of Pharmaceutics 516:1-2, 21-31. Online publication date: 1-Jan-2017. [CrossRef]
Fitsum Feleke Sahle, Michael Giulbudagian, Julian Bergueiro, Jürgen Lademann, Marcelo Calderón. (2017) Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle. Nanoscale 9:1, 172-182. Online publication date: 1-Jan-2017. [CrossRef]
Xuan Li, Ka Pang, Tsz Ng, Ping Leung, Cheng Zhang, Ken Leung, Lijian Jin. (2016) Cellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles. Nanomaterials 6:12, 192. Online publication date: 1-Dec-2016. [CrossRef]
Benjamin Balzus, Miriam Colombo, Fitsum Feleke Sahle, Gaith Zoubari, Sven Staufenbiel, Roland Bodmeier. (2016) Comparison of different in vitro release methods used to investigate nanocarriers intended for dermal application. International Journal of Pharmaceutics 513:1-2, 247-254. Online publication date: 1-Nov-2016. [CrossRef]
Matthias Radtke, Roland R. Netz. (2016) Ratchet effect for two-dimensional nanoparticle motion in a corrugated oscillating channel. The European Physical Journal E 39:11. Online publication date: 1-Nov-2016. [CrossRef]
Matthias Radtke, Alexa Patzelt, Fanny Knorr, Jürgen Lademann, Roland R. Netz. (2016) Ratchet effect for nanoparticle transport in hair follicles. European Journal of Pharmaceutics and Biopharmaceutics. Online publication date: 1-Oct-2016. [CrossRef]
Fitsum Feleke Sahle, Benjamin Balzus, Christian Gerecke, Burkhard Kleuser, Roland Bodmeier. (2016) Formulation and in vitro evaluation of polymeric enteric nanoparticles as dermal carriers with pH-dependent targeting potential. European Journal of Pharmaceutical Sciences 92, 98-109. Online publication date: 1-Sep-2016. [CrossRef]
Elina A. Genina, Yulia I. Svenskaya, Irina Yu. Yanina, Leonid E. Dolotov, Nikita A. Navolokin, Alexey N. Bashkatov, Georgy S. Terentyuk, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Valery V. Tuchin, Gleb B. Sukhorukov. (2016) In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express 7:6, 2082. Online publication date: 1-Jun-2016. [CrossRef]
R. Rotomskis. 2016. Quantum Dot Migration Through Natural Barriers and Distribution in the Skin. Nanoscience in Dermatology, 307-321. [CrossRef]
N. El-Sayed, L. El-Khourdagui, M. Schneider. 2016. Insights Into Interactions of Gold Nanoparticles With the Skin and Potential Dermatological Applications. Nanoscience in Dermatology, 99-113. [CrossRef]
C. Homyak, F. Anson, S. Thayumanavan. 2016. Supramolecular Polymers in Nanomedicine. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. [CrossRef]
M. Asadian-Birjand, J. Bergueiro, F. Rancan, J. C. Cuggino, R.-C. Mutihac, K. Achazi, J. Dernedde, U. Blume-Peytayi, A. Vogt, M. Calderón. (2015) Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration. Polym. Chem. 6:32, 5827-5831. Online publication date: 1-Jan-2015. [CrossRef]
Read More: http://www.worldscientific.com/doi/abs/10.1142/S1793545815300049
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